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Gastro-esophageal reflux disease with esophagitis

MedGen UID:
671270
•Concept ID:
C0677659
•
Disease or Syndrome
Synonyms: Esophageal reflux with esophagitis; Gastroesophageal reflux disease with esophagitis; Peptic esophagitis; Reflux esophagitis
SNOMED CT: Gastroesophageal reflux disease with esophagitis (266433003); Peptic esophagitis (266433003); Reflux esophagitis (266433003); Esophageal reflux with esophagitis (266433003); Gastro-esophageal reflux disease with esophagitis (266433003)

Professional guidelines

PubMed

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.
Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease.
Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ
Am J Gastroenterol 2022 Jan 1;117(1):27-56. doi: 10.14309/ajg.0000000000001538. PMID: 34807007Free PMC Article
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

Recent clinical studies

Etiology

Updates to the modern diagnosis of GERD: Lyon consensus 2.0.
Gyawali CP, Yadlapati R, Fass R, Katzka D, Pandolfino J, Savarino E, Sifrim D, Spechler S, Zerbib F, Fox MR, Bhatia S, de Bortoli N, Cho YK, Cisternas D, Chen CL, Cock C, Hani A, Remes Troche JM, Xiao Y, Vaezi MF, Roman S
Gut 2024 Jan 5;73(2):361-371. doi: 10.1136/gutjnl-2023-330616. PMID: 37734911Free PMC Article
Laparoscopic Nissen Versus Toupet Fundoplication for Short- and Long-Term Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis and Systematic Review.
Li G, Jiang N, Chendaer N, Hao Y, Zhang W, Peng C
Surg Innov 2023 Dec;30(6):745-757. Epub 2023 Mar 30 doi: 10.1177/15533506231165829. PMID: 36998190Free PMC Article
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Ong JS, An J, Han X, Law MH, Nandakumar P; 23andMe Research team; Esophageal cancer consortium, Schumacher J, Gockel I, Bohmer A, Jankowski J, Palles C, Olsen CM, Neale RE, Fitzgerald R, Thrift AP, Vaughan TL, Buas MF, Hinds DA, Gharahkhani P, Kendall BJ, MacGregor S
Gut 2022 Jun;71(6):1053-1061. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2020-323906. PMID: 34187846Free PMC Article
Antireflux surgery.
Gatenby PA, Bann SD
Minerva Chir 2009 Apr;64(2):169-81. PMID: 19365317
Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification.
Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L
Gut 1999 Aug;45(2):172-80. doi: 10.1136/gut.45.2.172. PMID: 10403727Free PMC Article

Diagnosis

Updates to the modern diagnosis of GERD: Lyon consensus 2.0.
Gyawali CP, Yadlapati R, Fass R, Katzka D, Pandolfino J, Savarino E, Sifrim D, Spechler S, Zerbib F, Fox MR, Bhatia S, de Bortoli N, Cho YK, Cisternas D, Chen CL, Cock C, Hani A, Remes Troche JM, Xiao Y, Vaezi MF, Roman S
Gut 2024 Jan 5;73(2):361-371. doi: 10.1136/gutjnl-2023-330616. PMID: 37734911Free PMC Article
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Ong JS, An J, Han X, Law MH, Nandakumar P; 23andMe Research team; Esophageal cancer consortium, Schumacher J, Gockel I, Bohmer A, Jankowski J, Palles C, Olsen CM, Neale RE, Fitzgerald R, Thrift AP, Vaughan TL, Buas MF, Hinds DA, Gharahkhani P, Kendall BJ, MacGregor S
Gut 2022 Jun;71(6):1053-1061. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2020-323906. PMID: 34187846Free PMC Article
Cow's Milk Allergy or Gastroesophageal Reflux Disease-Can We Solve the Dilemma in Infants?
Salvatore S, Agosti M, Baldassarre ME, D'Auria E, Pensabene L, Nosetti L, Vandenplas Y
Nutrients 2021 Jan 21;13(2) doi: 10.3390/nu13020297. PMID: 33494153Free PMC Article
Gastro-Esophageal Reflux in Children.
Rybak A, Pesce M, Thapar N, Borrelli O
Int J Mol Sci 2017 Aug 1;18(8) doi: 10.3390/ijms18081671. PMID: 28763023Free PMC Article
Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification.
Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L
Gut 1999 Aug;45(2):172-80. doi: 10.1136/gut.45.2.172. PMID: 10403727Free PMC Article

Therapy

Updates to the modern diagnosis of GERD: Lyon consensus 2.0.
Gyawali CP, Yadlapati R, Fass R, Katzka D, Pandolfino J, Savarino E, Sifrim D, Spechler S, Zerbib F, Fox MR, Bhatia S, de Bortoli N, Cho YK, Cisternas D, Chen CL, Cock C, Hani A, Remes Troche JM, Xiao Y, Vaezi MF, Roman S
Gut 2024 Jan 5;73(2):361-371. doi: 10.1136/gutjnl-2023-330616. PMID: 37734911Free PMC Article
Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss, Comorbidities, and Reflux at 10 Years in Adult Patients With Obesity: The SLEEVEPASS Randomized Clinical Trial.
Salminen P, Grönroos S, Helmiö M, Hurme S, Juuti A, Juusela R, Peromaa-Haavisto P, Leivonen M, Nuutila P, Ovaska J
JAMA Surg 2022 Aug 1;157(8):656-666. doi: 10.1001/jamasurg.2022.2229. PMID: 35731535Free PMC Article
Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021.
Iwakiri K, Fujiwara Y, Manabe N, Ihara E, Kuribayashi S, Akiyama J, Kondo T, Yamashita H, Ishimura N, Kitasako Y, Iijima K, Koike T, Omura N, Nomura T, Kawamura O, Ohara S, Ozawa S, Kinoshita Y, Mochida S, Enomoto N, Shimosegawa T, Koike K
J Gastroenterol 2022 Apr;57(4):267-285. Epub 2022 Feb 28 doi: 10.1007/s00535-022-01861-z. PMID: 35226174Free PMC Article
AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review.
Targownik LE, Fisher DA, Saini SD
Gastroenterology 2022 Apr;162(4):1334-1342. Epub 2022 Feb 17 doi: 10.1053/j.gastro.2021.12.247. PMID: 35183361
ESNM/ANMS consensus paper: Diagnosis and management of refractory gastro-esophageal reflux disease.
Zerbib F, Bredenoord AJ, Fass R, Kahrilas PJ, Roman S, Savarino E, Sifrim D, Vaezi M, Yadlapati R, Gyawali CP
Neurogastroenterol Motil 2021 Apr;33(4):e14075. Epub 2020 Dec 28 doi: 10.1111/nmo.14075. PMID: 33368919

Prognosis

Non-erosive gastro-oesophageal reflux disease and incidence of oesophageal adenocarcinoma in three Nordic countries: population based cohort study.
Holmberg D, Santoni G, von Euler-Chelpin M, Färkkilä M, Kauppila JH, Maret-Ouda J, Ness-Jensen E, Lagergren J
BMJ 2023 Sep 13;382:e076017. doi: 10.1136/bmj-2023-076017. PMID: 37704252Free PMC Article
Relationship Between Esophageal Disease and Pulmonary Fibrosis.
Zhou JC, Gavini S, Chan WW, Lo WK
Dig Dis Sci 2023 Apr;68(4):1096-1105. Epub 2023 Mar 14 doi: 10.1007/s10620-023-07908-2. PMID: 36918450
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Ong JS, An J, Han X, Law MH, Nandakumar P; 23andMe Research team; Esophageal cancer consortium, Schumacher J, Gockel I, Bohmer A, Jankowski J, Palles C, Olsen CM, Neale RE, Fitzgerald R, Thrift AP, Vaughan TL, Buas MF, Hinds DA, Gharahkhani P, Kendall BJ, MacGregor S
Gut 2022 Jun;71(6):1053-1061. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2020-323906. PMID: 34187846Free PMC Article
Esophageal Diseases.
Fitzgerald RC, Vaezi MF
Gastroenterology 2018 Jan;154(2):263-266. Epub 2017 Dec 21 doi: 10.1053/j.gastro.2017.12.017. PMID: 29274867
Reflux monitoring in children.
Singendonk MM, Benninga MA, van Wijk MP
Neurogastroenterol Motil 2016 Oct;28(10):1452-9. doi: 10.1111/nmo.12922. PMID: 27682990

Clinical prediction guides

Non-erosive gastro-oesophageal reflux disease and incidence of oesophageal adenocarcinoma in three Nordic countries: population based cohort study.
Holmberg D, Santoni G, von Euler-Chelpin M, Färkkilä M, Kauppila JH, Maret-Ouda J, Ness-Jensen E, Lagergren J
BMJ 2023 Sep 13;382:e076017. doi: 10.1136/bmj-2023-076017. PMID: 37704252Free PMC Article
Laparoscopic Nissen Versus Toupet Fundoplication for Short- and Long-Term Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis and Systematic Review.
Li G, Jiang N, Chendaer N, Hao Y, Zhang W, Peng C
Surg Innov 2023 Dec;30(6):745-757. Epub 2023 Mar 30 doi: 10.1177/15533506231165829. PMID: 36998190Free PMC Article
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Ong JS, An J, Han X, Law MH, Nandakumar P; 23andMe Research team; Esophageal cancer consortium, Schumacher J, Gockel I, Bohmer A, Jankowski J, Palles C, Olsen CM, Neale RE, Fitzgerald R, Thrift AP, Vaughan TL, Buas MF, Hinds DA, Gharahkhani P, Kendall BJ, MacGregor S
Gut 2022 Jun;71(6):1053-1061. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2020-323906. PMID: 34187846Free PMC Article
Reflux monitoring in children.
Singendonk MM, Benninga MA, van Wijk MP
Neurogastroenterol Motil 2016 Oct;28(10):1452-9. doi: 10.1111/nmo.12922. PMID: 27682990
Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification.
Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L
Gut 1999 Aug;45(2):172-80. doi: 10.1136/gut.45.2.172. PMID: 10403727Free PMC Article

Recent systematic reviews

Breathing Exercises in Gastroesophageal Reflux Disease: A Systematic Review.
Zdrhova L, Bitnar P, Balihar K, Kolar P, Madle K, Martinek M, Pandolfino JE, Martinek J
Dysphagia 2023 Apr;38(2):609-621. Epub 2022 Jul 16 doi: 10.1007/s00455-022-10494-6. PMID: 35842548Free PMC Article
Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis.
Eusebi LH, Ratnakumaran R, Yuan Y, Solaymani-Dodaran M, Bazzoli F, Ford AC
Gut 2018 Mar;67(3):430-440. Epub 2017 Feb 23 doi: 10.1136/gutjnl-2016-313589. PMID: 28232473
Lifestyle Intervention in Gastroesophageal Reflux Disease.
Ness-Jensen E, Hveem K, El-Serag H, Lagergren J
Clin Gastroenterol Hepatol 2016 Feb;14(2):175-82.e1-3. Epub 2015 May 6 doi: 10.1016/j.cgh.2015.04.176. PMID: 25956834Free PMC Article
Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.
El-Serag HB, Sweet S, Winchester CC, Dent J
Gut 2014 Jun;63(6):871-80. Epub 2013 Jul 13 doi: 10.1136/gutjnl-2012-304269. PMID: 23853213Free PMC Article
The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus.
Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group
Am J Gastroenterol 2006 Aug;101(8):1900-20; quiz 1943. doi: 10.1111/j.1572-0241.2006.00630.x. PMID: 16928254

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